Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013–2014 malaria season
Identifieur interne : 000E54 ( Main/Exploration ); précédent : 000E53; suivant : 000E55Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013–2014 malaria season
Auteurs : Bécaye Fall [Sénégal] ; Cheikhou Camara [Sénégal] ; Mansour Fall [Sénégal] ; Aminata Nakoulima [Sénégal] ; Pierre Dionne [Sénégal] ; Bakary Diatta [Sénégal] ; Yaya Diemé [Sénégal] ; Boubacar Wade [Sénégal] ; Bruno Pradines [Sénégal]Source :
- Malaria Journal [ 1475-2875 ] ; 2015-02-16.
Descripteurs français
- Wicri :
- geographic : Sénégal.
English descriptors
- mix :
Abstract
Background: In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. Since the introduction of ACT, there have been very few reports on the level of Plasmodium falciparum resistance to anti-malarial drugs. An ex vivo susceptibility study was conducted on local isolates obtained from the Hôpital Principal de Dakar (Dakar, Senegal) from November 2013 to January 2014. Methods: Eighteen P. falciparum isolates were sussessfully assessed for ex vivo susceptibility to chloroquine (CQ), quinine (QN), monodesethylamodiaquine (MDAQ), the active metabolite of amodiaquine, mefloquine (MQ), lumefantrine (LMF), artesunate (AS), dihydroartemisinin (DHA), the active metabolite of artemisinin derivatives, pyronaridine (PND), piperaquine (PPQ), and, Proveblue (PVB), a methylene blue preparation, using the HRP2-based ELISA test. Results: The prevalence of isolates with reduced susceptibility was 55.6% for MQ, 50% for CQ, 5.6% for QN and MDAQ, and 0% for DHA, AS and LMF. The mean IC 50 for PND, PPQ and PVB were 5.8 nM, 32.2 nM and 5.3 nM, respectively. Conclusions: The prevalence of isolates with a reduced susceptibility to MQ remains high and stable in Dakar. Since 2004, the prevalence of CQ resistance decreased, but rebounded in 2013 in Dakar. PND, PPQ and PVB showed high in vitro activity in P. falciparum parasites from Dakar.
Url:
DOI: 10.1186/s12936-015-0589-3
Affiliations:
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B.P. 3006 - DAKAR (Sénégal)</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.hopitalprincipal.sn/</ref> </desc> </org></tutelle><tutelle active="#struct-352262" type="direct"><org type="institution" xml:id="struct-352262" status="INCOMING"> <orgName>Fédération des laboratoires</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author><author><name sortKey="Camara, Cheikhou" sort="Camara, Cheikhou" uniqKey="Camara C" first="Cheikhou" last="Camara">Cheikhou Camara</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-214454" status="INCOMING"> <orgName>Service des Urgences</orgName> <desc> <address> <addrLine>Rte de la Corniche Est, Dakar</addrLine> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-338318" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-338318" type="direct"><org type="institution" xml:id="struct-338318" status="VALID"> <orgName>Hôpital Principal de Dakar</orgName> <desc> <address> <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.hopitalprincipal.sn/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author><author><name sortKey="Fall, Mansour" sort="Fall, Mansour" uniqKey="Fall M" first="Mansour" last="Fall">Mansour Fall</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440279" status="INCOMING"> <orgName>Service de Réanimation Médicale</orgName> <desc> <address> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-338318" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-338318" type="direct"><org type="institution" xml:id="struct-338318" status="VALID"> <orgName>Hôpital Principal de Dakar</orgName> <desc> <address> <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.hopitalprincipal.sn/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author><author><name sortKey="Nakoulima, Aminata" sort="Nakoulima, Aminata" uniqKey="Nakoulima A" first="Aminata" last="Nakoulima">Aminata Nakoulima</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-224319" status="INCOMING"> <orgName>Service de pédiatrie</orgName> <desc> <address> <addrLine>Rte de la Corniche Est, Dakar</addrLine> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-338318" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-338318" type="direct"><org type="institution" xml:id="struct-338318" status="VALID"> <orgName>Hôpital Principal de Dakar</orgName> <desc> <address> <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.hopitalprincipal.sn/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author><author><name sortKey="Dionne, Pierre" sort="Dionne, Pierre" uniqKey="Dionne P" first="Pierre" last="Dionne">Pierre Dionne</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440281" status="INCOMING"> <orgName>Maternité Hôpital Principal de Dakar</orgName> <desc> <address> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-440280" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-440280" type="direct"><org type="institution" xml:id="struct-440280" status="INCOMING"> <orgName>Maternité Hôpital Principal de Dakar</orgName> <desc> <address> <country key="SN"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author><author><name sortKey="Diatta, Bakary" sort="Diatta, Bakary" uniqKey="Diatta B" first="Bakary" last="Diatta">Bakary Diatta</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440279" status="INCOMING"> <orgName>Service de Réanimation Médicale</orgName> <desc> <address> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-338318" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-338318" type="direct"><org type="institution" xml:id="struct-338318" status="VALID"> <orgName>Hôpital Principal de Dakar</orgName> <desc> <address> <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.hopitalprincipal.sn/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author><author><name sortKey="Dieme, Yaya" sort="Dieme, Yaya" uniqKey="Dieme Y" first="Yaya" last="Diemé">Yaya Diemé</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-214449" status="INCOMING"> <orgName>Laboratoire d'étude de la chimiosensibilité du paludisme</orgName> <desc> <address> <addrLine>Rte de la Corniche Est, Dakar</addrLine> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-338318" type="direct"></relation> <relation active="#struct-352262" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-338318" type="direct"><org type="institution" xml:id="struct-338318" status="VALID"> <orgName>Hôpital Principal de Dakar</orgName> <desc> <address> <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.hopitalprincipal.sn/</ref> </desc> </org></tutelle><tutelle active="#struct-352262" type="direct"><org type="institution" xml:id="struct-352262" status="INCOMING"> <orgName>Fédération des laboratoires</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author><author><name sortKey="Wade, Boubacar" sort="Wade, Boubacar" uniqKey="Wade B" first="Boubacar" last="Wade">Boubacar Wade</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-214459" status="INCOMING"> <orgName>Chefferie</orgName> <desc> <address> <addrLine>Rte de la Corniche Est, Dakar</addrLine> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-338318" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-338318" type="direct"><org type="institution" xml:id="struct-338318" status="VALID"> <orgName>Hôpital Principal de Dakar</orgName> <desc> <address> <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.hopitalprincipal.sn/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author><author><name sortKey="Pradines, Bruno" sort="Pradines, Bruno" uniqKey="Pradines B" first="Bruno" last="Pradines">Bruno Pradines</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-214449" status="INCOMING"> <orgName>Laboratoire d'étude de la chimiosensibilité du paludisme</orgName> <desc> <address> <addrLine>Rte de la Corniche Est, Dakar</addrLine> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-338318" type="direct"></relation> <relation active="#struct-352262" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-338318" type="direct"><org type="institution" xml:id="struct-338318" status="VALID"> <orgName>Hôpital Principal de Dakar</orgName> <desc> <address> <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.hopitalprincipal.sn/</ref> </desc> </org></tutelle><tutelle active="#struct-352262" type="direct"><org type="institution" xml:id="struct-352262" status="INCOMING"> <orgName>Fédération des laboratoires</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author></analytic><idno type="DOI">10.1186/s12936-015-0589-3</idno><series><title level="j">Malaria Journal</title><idno type="ISSN">1475-2875</idno><imprint><date type="datePub">2015-02-16</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Anti-malarial</term><term>In vitro</term><term>Malaria</term><term>Methylene blue</term><term>Plasmodium falciparum</term><term>Proveblue</term><term>Resistance</term><term>Senegal</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Sénégal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Background: In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. Since the introduction of ACT, there have been very few reports on the level of Plasmodium falciparum resistance to anti-malarial drugs. An ex vivo susceptibility study was conducted on local isolates obtained from the Hôpital Principal de Dakar (Dakar, Senegal) from November 2013 to January 2014. Methods: Eighteen P. falciparum isolates were sussessfully assessed for ex vivo susceptibility to chloroquine (CQ), quinine (QN), monodesethylamodiaquine (MDAQ), the active metabolite of amodiaquine, mefloquine (MQ), lumefantrine (LMF), artesunate (AS), dihydroartemisinin (DHA), the active metabolite of artemisinin derivatives, pyronaridine (PND), piperaquine (PPQ), and, Proveblue (PVB), a methylene blue preparation, using the HRP2-based ELISA test. Results: The prevalence of isolates with reduced susceptibility was 55.6% for MQ, 50% for CQ, 5.6% for QN and MDAQ, and 0% for DHA, AS and LMF. The mean IC 50 for PND, PPQ and PVB were 5.8 nM, 32.2 nM and 5.3 nM, respectively. Conclusions: The prevalence of isolates with a reduced susceptibility to MQ remains high and stable in Dakar. Since 2004, the prevalence of CQ resistance decreased, but rebounded in 2013 in Dakar. PND, PPQ and PVB showed high in vitro activity in P. falciparum parasites from Dakar.</p> </div></front></TEI><affiliations><list><country><li>Sénégal</li></country></list><tree><country name="Sénégal"><noRegion><name sortKey="Fall, Becaye" sort="Fall, Becaye" uniqKey="Fall B" first="Bécaye" last="Fall">Bécaye Fall</name></noRegion><name sortKey="Camara, Cheikhou" sort="Camara, Cheikhou" uniqKey="Camara C" first="Cheikhou" last="Camara">Cheikhou Camara</name><name sortKey="Diatta, Bakary" sort="Diatta, Bakary" uniqKey="Diatta B" first="Bakary" last="Diatta">Bakary Diatta</name><name sortKey="Dieme, Yaya" sort="Dieme, Yaya" uniqKey="Dieme Y" first="Yaya" last="Diemé">Yaya Diemé</name><name sortKey="Dionne, Pierre" sort="Dionne, Pierre" uniqKey="Dionne P" first="Pierre" last="Dionne">Pierre Dionne</name><name sortKey="Fall, Mansour" sort="Fall, Mansour" uniqKey="Fall M" first="Mansour" last="Fall">Mansour Fall</name><name sortKey="Nakoulima, Aminata" sort="Nakoulima, Aminata" uniqKey="Nakoulima A" first="Aminata" last="Nakoulima">Aminata Nakoulima</name><name sortKey="Pradines, Bruno" sort="Pradines, Bruno" uniqKey="Pradines B" first="Bruno" last="Pradines">Bruno Pradines</name><name sortKey="Wade, Boubacar" sort="Wade, Boubacar" uniqKey="Wade B" first="Boubacar" last="Wade">Boubacar Wade</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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